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Why did a promising heart drug fail?

Doomed drug highlights complications of meddling with cholesterol.

Questions 1-7

This passage has 7 paragraphs 1-7.

Choose the correct heading for each paragraph from the list of headings below.

Write the correct number i-ix in boxes 1-7 on your answer sheet.

List of Headings

i. How does torcetrapib work?

ii. Contradictory result prior to the current trial

iii. One failure may possibly bring about future success

iv. The failure doesn’t lead to total loss of confidence

v. It is the right route to follow

vi. Why it’s stopped

vii. They may combine and theoretically produce ideal result

viii. What’s wrong with the drug

ix. It might be wrong at the first place

Example answer

Paragraph 1 iv

1. Paragraph 2

2. Paragraph 3

3. Paragraph 4

4. Paragraph 5

5. Paragraph 6

6. Paragraph 7

Questions 7-13

Match torcetrapib，HDLs，statin and CETP with their functions (Questions 8-13)..

Write the correct letter A, B, C or D in boxes 8-13 on your answer sheet.

NB You may use any letter more than once.

7.It has been administered to over 10,000 subjects in a clinical trial.

8.It could help rid human body of cholesterol.

9.Researchers are yet to find more about it.

10. It was used to reduce the level of cholesterol.

11. According to Kashyap, it might lead to unwanted result if it’s blocked.

12. It produced contradictory results in different trials.

13. It could inhibit LDLs.

List of choices

A. Torcetrapic

B. HDLS

C. Statin

D. CETP

Suggested Answers and Explanations

1. vi

2. ii

3. vii 本段介绍了torcetrapib和statin的治病原理，但是同时短语“in contrast”与之前第二段后半段的内容呼应，暗示了这两种药在理论上能相辅相成，是理想的搭配。第一个选项无法涵盖整段意义，故选择i是错误的。

4. iii 本段分析了可能导致torcetrapibl临床试验失败的原因，后半段指出如果以上推测正确，那么未来的药物可借鉴这个试验，设法避免torcetrapib的缺陷，研制出有效的药物。viii选项无法涵盖后半段的意思。

5. ix 见首句。

6. v

7. A 见第二段。题目中administer一词意为“用药”，subject一词为“实验对象”之意。

8. B 见第四段“… to raise levels of HDLs, which ferry cholesterol out of artery-clogging plaques to the liver for removal from the body.”即HDLs的作用最终是将choleserol清除出人体：“… for removal from the body”。

9. B 见第四段“But HDLs are complex and not entirely understood.”

10. C 见第二段“… plus a cholesterol-lowering statin”，即statin是可以降低cholesterol的。

11. D 见第六段“So inhibiting CETP, … might actually cause an abnormal and irreversible accumulation of cholesterol in the body.

12. A 见第三段。

13. C 见第四段“Statins, in contrast, mainly work by lowering the \'bad\' low-density lipoproteins.”

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